Dynavax Technologies Corporation (Nasdaq:DVAX) today announced the termination of a global license and development collaboration agreement with Merck & Co., Inc. for HEPLISAVTM, a Phase 3 hepatitis B virus (HBV) vaccine. All rights to develop and commercialize HEPLISAV revert to Dynavax.
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While examining patterns of DNA modification in lung cancer, a team of international researchers has discovered what they say is a surprising new mechanism. They say that “silencing” of a single gene in lung cancer led to a general impairment in genome-wide changes in cells, contributing to cancer development and progression. In the January 1, 2009, issue of
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Ask someone where their ancestors were from and odds are that they know. Or maybe not. A new study published in Human Molecular Genetics suggests that scientists using the latest tools to scan the human genome must pay attention to ancestry when analyzing and interpreting their results. Chao Tian and Michael F. Seldin, MD, PhD, of University of California Davis, and Peter K.
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A research group lead by scientists at the University of Warwick has discovered the trigger that pulls together X chromosomes in female cells at a crucial stage of embryo development. Their discovery could also provide new insights into how other similar chromosomes spontaneously recognize each other and are bound together at key parts of analogous cell processes.
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US researchers studying the effect of beta carotene, vitamin C and vitamin E, either singly or in combination, on over 7,000 women found the supplements did not reduce their risk of getting cancer compared to women who did not take the supplements. However an expert who reviewed the study said that while the overall message was there was no link, it uncovered some interesting evidence that should not be overlooked.
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The probability of having one’s child receive an attention deficit hyperactivity disorder (ADHD) diagnosis involves a mother’s own medical conditions and her use of health services prior to having the child, a new study finds. What is not clear, however, is whether the effects are due to biological, environmental or psychosocial factors – or some combination of these.
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Scientists in Japan are reporting an advance toward using a natural disease-fighting protein in pills or syrups that patients can take by mouth rather than injection. Their study is the first to show that coating the protein with a polymer material already in wide medical use can increase its absorption by the intestine. The research appears in the current issue of ACS’ Bioconjugate Chemistry, a monthly journal.
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A team of scientists from the US and Japan have identified a combination of three genes in the flu virus that was most likely responsible for making the 1918 flu strain so deadly that it caused the most devastating outbreak of infectious disease ever known to humankind, leaving tens of millions dead in its wake.
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Using genome-wide association for the first time to scan for genes implicated in high blood pressure, and studying both Amish and non-Amish people, US scientists have discovered a gene involved in regulating how kidneys process salt whose variant they suggest is linked to high blood pressure risk.
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Investigators at Georgia State University’s Neuroscience Institute and Center for Behavioral Neuroscience are the first to identify the most likely reason analgesic drug treatment is usually less potent in females than males. This discovery is a major step toward finding more effective treatments for females suffering from persistent pain.
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